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Clexane

s a type of medicine that is sold and administered in injectable doses. Its main health benefit comes from its anticoagulant properties . It prevents the formation of thrombi in a wide variety of patients, although it also has certain contraindications.

People treated with clexane often need to have tests to keep track of platelets and potassium in their blood .

Main uses of the Clexane

  • Deep venous thrombosis.
  • Pulmonary embolism
  • Prevention of thromboembolism, especially in periods after general surgery or surgery on the bones (orthopedic surgery) or in immobile or bedridden people due to diseases.
  • Treatment of blood clots in the coronary arteries in unstable angina and heart attack ( myocardial infarction ).
  • Prevention of blood clotting when filtered through a dialysis machine as part of the treatment of kidney failure.

Active ingredient

The injectable dose of Clexane contains the active ingredient enoxaparin , a drug called low molecular weight heparin. Its function is to stop the formation of blood clots inside the blood vessels .

Normally, blood clots only form to stop bleeding that results from tissue injury. The clotting process is complicated and begins when blood cells called platelets clump together and produce chemicals that activate the clotting process.

The final part of this process involves a substance called thrombin that is activated to produce a protein called fibrin. Fibrin binds platelets, forming a blood clot . This is the mechanism that the human body has to recover.

Sometimes, however, a blood clot can form abnormally within the blood vessels. This is known as a thrombus. It can be dangerous, because the clot can separate and travel through the bloodstream, becoming known as an embolus.

The plunger can be placed in a blood vessel, thus blocking the blood supply to a vital organ such as the heart, brain, or lungs . This is when a thromboembolism occurs.

There are people with a greater tendency to suffer clots. This is generally due to a disturbance in blood flow. For example, in coronary artery disease, fatty deposits (atherosclerosis) on the walls of the coronary arteries can disrupt blood flow, causing platelets to clump together and begin the clotting process.

When a clot forms in a coronary artery, it reduces blood flow to the heart and causes chest pain (angina). This can cause a heart attack.

Slow blood flow in the veins of the legs and pelvis can also lead to clots in these veins (deep vein thrombosis). These clots can travel to the lungs (pulmonary embolism).

Being immobile for long periods of time, for example due to a serious medical condition or after surgery, can increase the risk of these types of blood clots, as can pregnancy, obesity, and certain circulatory disorders.

Enoxaparin

Enoxaparin can prevent and treat these types of abnormal blood clots. It works by inactivating thrombin in the clotting process described above. This stops the formation of fibrin, the essential component of blood clots.

How to administer Clexane

Clexane enters the body through a needle that is punctured into the skin of the abdomen . The dose and duration of treatment used depend on the nature of the clot being treated or prevented.

Risk groups in the use of Clexane

Clexane poses a risk when administered to the following groups of patients:

  • Older than 80 years.
  • People who are underweight or overweight.
  • People with decreased kidney function or chronic kidney failure.
  • People with decreased liver function.
  • People who have previously developed a low blood platelet count due to treatment with heparin or low molecular weight heparin (heparin-associated thrombocytopenia).
  • People with trouble stopping bleeding.
  • People with a history of peptic ulcer.
  • People who have just had a stroke caused by a blood clot in the brain (ischemic stroke).
  • People with severe and uncontrolled high blood pressure (hypertension).
  • People with diabetes and diabetic retinopathy .
  • People who have just had eye surgery.
  • People who have just had surgery on the brain or spinal cord (neurosurgery).
  • People with spinal or epidural anesthesia.
  • People with a high level of potassium in the blood (hyperkalemia).
  • People with increased acidity in the blood (metabolic acidosis).

Groups in which the use of Clexane is contraindicated

  • People allergic to heparin or other low molecular weight heparins.
  • People with a bacterial infection of the heart valves and the lining around the heart ( bacterial endocarditis ).
  • People with active major bleeding.
  • People at high risk of uncontrolled bleeding.
  • Kids.
  • People with an artificial heart valve.
  • People allergic to some of the ingredients in Clexane.

Practice and breastfeeding

There are medications that can be used during pregnancy or breastfeeding, as long as the benefits to the mother outweigh the risks to the fetus.

However, Clexane is not recommended for preventing blood clots in pregnant women with artificial heart valves , because there is not enough information on its use in this particular case. And it has not been studied in women during breastfeeding.

Still, it is unlikely that this drug passed into breast milk. And if it did, it would lose its properties in the baby’s intestine.

Always under medical supervision

In any case, you should always seek medical supervision and ask for information , in case of any adverse effect that the patient perceives.

For example, before taking Clexane, the patient should provide the specialist doctor with all the necessary information about their medical history and, especially, if they have suffered from allergies. And if you are already administering it and you notice an adverse or allergic reaction, you should immediately inform the doctor or pharmacist, to avoid possible complications.

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Hello Readers, I am Nikki Bella a Psychology student. I have always been concerned about human behavior and the mental processes that lead us to act and think the way we do. My collaboration as an editor in the psychology area of ​​Well Being Pole has allowed me to investigate further and expand my knowledge in the field of mental health; I have also acquired great knowledge about physical health and well-being, two fundamental bases that are directly related and are part of all mental health.

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